Carson R. Takaoka

Telescoped Two-Step Deaminative Ni-Catalyzed C(sp 2 )–C(sp 3 ) Cross-Electrophile Coupling for Late-Stage Parallel Library Synthesis

Abstract A two-step deaminative C(sp2)–C(sp3) cross-electrophile coupling (XEC) protocol to enable late-stage parallel library diversification of medicinally relevant aryl halides is reported. In the first step, sodium pivalate facilitates the condensation of primary amines with...