Carolina Tafalla

Development of a polyclonal antibody-based sandwich ELISpot assay for interleukin-4/13B1 in rainbow trout Oncorhynchus mykiss

Abstract In mammals, interleukin-4 (IL-4) and IL-13 are important Th2 cytokines that enhance antibody production by B cells and proliferation of Th2 cells. Salmonid fish have three homologs to both of these cytokines as a result of four rounds of whole genome duplication events,...

Viperin as a putative antiviral effector in rainbow trout (Oncorhynchus mykiss) cells identified by CRISPR-Cas9 functional analysis following exposure to inactivated viral hemorrhagic septicemia virus

Abstract Viperin is recognized for its potent broad-spectrum antiviral activity; however, its role in the antiviral immune response of rainbow trout ( Oncorhynchus mykiss ) remains poorly characterized. In this study, the contribution of viperin to the innate immune response agai...