Carolien H. M. van Deurzen

Lobular cancerization in biopsy-diagnosed ductal carcinoma in situ (DCIS) of the breast: a detailed histopathological evaluation and reproducibility study

The role of lobular cancerization in ductal carcinoma in situ (DCIS) of the breast is poorly described to date. A precise definition is lacking. We explored the association between lobular cancerization in biopsy-diagnosed DCIS and different other histopathological features, as w...

Guidance for laboratory implementation, governance and continuous assurance of artificial intelligence in histopathology

Abstract Artificial intelligence (AI) is rapidly transforming histopathology, with applications ranging from workflow optimisation and quality assurance to tumour diagnosis, grading, biomarker assessment and estimation of prognosis. While numerous AI algorithms have demonstrated...

Management of high-risk (B3) breast lesions in symptomatic practice: evidence review and practical recommendations for multidisciplinary care

Borderline breast lesions (B3 lesions, also termed lesions of uncertain malignant potential or high-risk lesions) represent a heterogeneous group of entities associated with variable risks of malignancy. While the management of screen-detected B3 lesions has become increasingly s...