Carmen Corciulo

Assessing the translational value of animal models in developing pain-targeting therapies for clinical osteoarthritis

Abstract Osteoarthritis (OA) is a highly prevalent and disabling disease, with pain as its most debilitating symptom. Despite extensive preclinical research, no therapy has successfully translated from animal models into routine clinical use. Commonly used animal models (e.g., ac...

Progesterone Modulates Protein Synthesis in Osteoarthritic Fibroblast-like Synoviocytes

Knee osteoarthritis (OA) is highly prevalent in women and is characterized by structural joint alterations and synovial inflammatory processes that contribute to pain and impaired mobility. In a previous study, we identified a positive correlation between progesterone levels and...