Carlos Alberto Peralta-Alvarez

Mapping early PRC2 nucleation sites upon Suz12 reintroduction reveals features of de novo Polycomb recruitment

Polycomb domains safeguard cell identity by maintaining lineage-specific chromatin states enriched in repressive histone modifications, preserving the epigenetic memory of cell lineages. While Polycomb repressive complex 2 (PRC2) can reestablish its occupancy after perturbation,...