Carl M. J. Kirkpatrick

Deprescribing interventions in older adults with cancer: A systematic review and meta-analysis

Introduction Polypharmacy and use of potentially inappropriate medications (PIMs) in older adults with cancer are associated with increased morbidity and mortality. Deprescribing is a structured, patient-centred intervention for reducing PIMs; however, the outcomes of deprescribi...

The Governance Gap: Democratizing Drug Development Through Decision Architecture

Drug development is most exposed to governance failure where it can least afford it, in global health. The field has more predictive power than at any point in its history and roughly the same failure rate it had a decade ago. We argue that this paradox persists because the field...