Cao Guang-yi

Integrative Single-Cell Proteomics and Network Analysis Identifies DHX9 as a Key Regulator of Oocyte Maturation and a Therapeutic Target for Oocyte Developmental Arrest

Abstract Oocyte developmental arrest at the germinal vesicle (GV) or metaphase I (MI) stage is a major cause of infertility, yet its molecular mechanisms remain poorly understood. Here, we performed ultradeep single-cell proteomics on 8 human oocytes (4 GV-stage and 4 MI-stage) a...