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Design, Synthesis, and Biological Evaluation of Novel Tetrazole-Containing Tetrahydroisoquinoline Derivatives as Putative CYP51 Inhibitors against Candida Species

Abstract To address the need for structurally diverse tetrazole-based CYP51 inhibitors with reduced CYP inhibition liability, we designed and synthesized a series of tetrazole-tetrahydroisoquinoline derivatives. Starting from the metabolically unstable lead A33 (t1/2 = 2.89 min),...