Cameron S. McAlpine

Modeling the Exposome in Murine Cardiovascular Disease

Our exposome, encompassing our environmental and lifestyle exposures across the life span, is a critical determinant of cardiovascular health. Clinical and epidemiological data demonstrate that sleep, stress, exercise, smoking, viral respiratory infections, and environmental poll...

Effects of early adulthood chronic sleep disruption on late life cognition, brain pathology, and microglial reactivity in the PS19 mouse model of tauopathy

Abstract A bidirectional relationship has been proposed between sleep and Alzheimer’s disease pathology, such that disruption to sleep can lead to increases in the expression of tau or its phosphorylation. Over the long term, this can potentially lead to greater expression of neu...