Buu Minh Thanh Truong

Genome-Wide Association Study Meta-Analysis of Central Serous Chorioretinopathy

Abstract Objective To define CSC genetic architecture and identify implicated ocular tissues, cell types, genes, and circulating proteins. Data Sources Genome-wide data were assembled from FinnGen, All of Us, Mass General Brigham Biobank, Million Veteran Program, and a Dutch chro...

Fine-tuning of polygenic score to local data improves risk prediction and clinical implementation

Polygenic risk scores (PRS) hold promise for stratifying inherited disease risk, yet their clinical adoption remains constrained by poor transferability across populations and cohorts. To bridge this gap, we propose a pragmatic framework that recalibrates externally derived PRSs...

Machine learning–driven spleen imaging and genomics uncover a splenic connection to coronary artery disease

Despite advances in managing traditional risk factors, coronary artery disease (CAD) remains the leading cause of mortality. Circulating hematopoietic cells influence risk for CAD separately from traditional risk factors, but the role of a key regulating organ, the spleen, is unk...