Buchanelli Rachi Reddy

Concise Total Syntheses of (±)-Hirsuteine, (±)-Hirsutine, (±)-Corynantheine, and (±)-Dihydrocorynantheine

Abstract A concise and protecting-group-free synthesis of the four corynanthe alkaloids has been developed from a readily available indole precursor. The key step features a reagent-controlled cascade Hosomi–Sakurai/Pictet–Spengler cyclization that simultaneously constructs the C...