Bruno Pagano

Hit It before It Starts: Targeting a (3 + 1) Hybrid Non-canonical G-Quadruplex to Silence PARP1 in Cancer

Abstract Error-prone DNA repair pathways promote genomic instability and cancer progression. Notably, Poly(ADP-ribose) polymerase-1 (PARP1)-directed alternative non-homologous end joining plays a pivotal role in cancer, including Multiple Myeloma (MM), conferring vulnerability to...