Brock C. Christensen

Integrated differential transcript usage and transcript abundance analyses reveal isoform-level remodeling in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is characterized by transcriptional reprogramming driven by hypoxia signaling, metabolic rewiring, and immune modulation. While gene-level analyses have defined key features of ccRCC biology, they do not capture isoform-level variation aris...

Equivalence of DNA-based cytometry to clinical flow cytometry and CBC for immune cell quantification in peripheral blood

Clinical flow cytometry, the current standard for immune cell typing and quantification, requires intact cell membranes, complex reagents, and substantial infrastructure, making it a costly, technically demanding process. In contrast, methylation cytometry only requires the measu...