Bram Vervliet

The HDAC inhibitor sodium butyrate moderately enhances long-term fear extinction memory retrieval in humans

Fear extinction and its persistence depend on epigenetic modifications, which can be potentiated by histone deacetylase inhibitors (HDACis). Butyrate (NaBu), a short-chain fatty acid and endogenous HDACi, promotes persistent fear extinction in rodent models by increasing histone...