Bradley R. Groveman

Knock-Out of Prion Protein Associated with Reactivity and Mitochondrial Abnormalities in a Novel Human Astrocyte Model

Human prion diseases are fatal neurodegenerative diseases caused by misfolding and aggregation of the cellular prion protein, PrP. Current therapeutic avenues focus on the removal of PrP to decrease its availability in the brain. Numerous studies have investigated the role of neu...