Bozhi Ye

Cardiomyocyte-enriched OTUD5 alleviates pathological myocardial hypertrophy by deubiquitinating STAT3 and modulating the STAT3–PGC-1α axis

Abstract Pathological cardiac hypertrophy presents a important public health challenge, particularly in aging populations, highlighting the urgent need for novel therapeutic targets. This study investigates the role and molecular mechanisms of OTUD5 in pathological cardiac hypert...

Enteric-gated nano–probiotic living nanozyme for gut-directed redox–mitochondrial protection in cisplatin-induced acute kidney injury

Oral nano-biohybrid therapeutics provide opportunities for gut–organ axis intervention, but gastrointestinal transit often compromises both probiotic viability and nanozyme activity. Here, we developed CeO 2 @LP@EL, an enteric-gated nano–probiotic living nanozyme constructed by d...