Bowen Yang

Mannosylated Spleen-Targeted Lipid Nanoparticles Enable Enhanced mRNA Delivery to Antigen-Presenting Cells

Abstract Targeted delivery of lipid nanoparticles (LNP) to immune organs remains challenging, and here we introduce a mannosylated spleen-targeted LNP (LNP-PAM) that integrates active and endogenous targeting to enhance mRNA delivery to antigen-presenting cells. A mannose-conjuga...