Bobo Gu

Label-free ovarian cancer histopathological diagnosis using two-photon autofluorescence microscopy with a joint denoising and segmentation framework

Two-photon autofluorescence (TPAF) microscopy is a promising modality for rapid, label-free assessment of unstained tissue, but is fundamentally limited by the poor visibility of nuclei, which are one of the gold-standard cancer biomarkers, due to their negative contrast nature....