Bo Zhang

15-PGDH inhibition in osteoarthritis: PGE2 skeletal interoception, cartilage regeneration and compartment-managed disease modification

Abstract Osteoarthritis is a whole-joint disease in which cartilage loss, synovial inflammation, subchondral bone remodelling and pain-related neural changes co-evolve, yet structural improvement does not reliably translate into pain relief. This Review centres prostaglandin E 2...

Early phosphate supplementation after newly detected hypophosphatemia in older ICU patients: a target trial emulation

Hypophosphatemia is common in critical illness, but whether initiating replacement promptly after a newly available low result improves clinical outcomes is uncertain. We used target trial emulation to estimate a per-protocol contrast in older intensive care unit (ICU) patients....