Bo Wang

HomocamptothecinPayloads with Enhanced Potency forAntibody-Drug Conjugates

Abstract Camptothecin derivatives, exemplified by DXd, are a dominant class of payloads for antibody-drug conjugates (ADCs). Herein, we describe the design and synthesis of H2, a novel homocamptothecin featuring a simplified hydroxybutyl structure that circumvents the complex ass...