Bo Tian

Magnetization Dynamics-Modulated Near-Infrared Mie Scattering Enables Homogeneous Femtomolar Immunosensing for Whole Blood

Abstract Low-abundance biomarkers in whole blood hold immense clinical value for disease diagnosis. However, their detection remains constrained by the difficulty of conventional assays in simultaneously achieving high sensitivity, rapid turnaround, and operational simplicity. He...

Enzymatic Ligation-Enhanced Catalytic Hairpin Assemblyfor Accelerated Kinetics with Restricted Leakage

Abstract Enthalpy-driven catalytic hairpin assembly (CHA) suffers from an inherent trade-off, wherein enhanced reaction kinetics is inevitably accompanied by elevated nonspecific background. Catalytic hairpin assembly-and-cyclization (CHAC) integrates CHA with enzymatic ligation,...