Bo Li

Dose-conditioned machine-learning prediction of a composite target sedation state in patients undergoing propofol-sedated gastrointestinal endoscopy

BACKGROUND: During propofol-sedated gastrointestinal endoscopy, adequate sedation must be achieved without compromising hemodynamic stability or oxygenation. We developed and temporally validated dose-conditioned machine-learning models to predict a composite target sedation stat...

Single-cell transcriptomics uncovers HPV-driven immune evasion and establishes a TAB2-based prognostic signature in cervical cancer

Background Persistent human papillomavirus (HPV) infection is a key driver in cervical cancer, yet the molecular mechanisms linking HPV to immune escape remain incompletely understood. Methods We integrated single-cell RNA sequencing (scRNA-seq), bulk transcriptome, and clinical...