Bjorn C. Knollmann

Metabolic stress exacerbates Ca 2+ dysregulation and arrhythmias in catecholaminergic polymorphic ventricular tachycardia

Abstract Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic arrhythmic syndrome caused by mutations in the sarcoplasmic reticulum (SR) calcium (Ca 2+ ) release channel RyR2 or its accessory proteins, including calsequestrin‐2 (CASQ2). RyR2 dysfunction or le...