Biprajit Sarkar

Chiral Rh Diene NHC Complexes and Their Application in Rh-Catalyzed Cycloisomerization of Enynes

Abstract Chiral dienes and N-heterocyclic carbenes (NHC) are important ligands for transition-metal catalysis. Surprisingly, both ligand classes are rarely employed together in Rh complexes. To get more detailed insight into the interaction between NHC and diene ligand simultaneo...

Introducing Diradicaloid Thiele's Hydrocarbon Derivatives as Ligand in Transition Metal Chemistry

Thiele's hydrocarbon (TH) derivatives, or p-quinodimethanes, are prototypical members of the organic diradicaloid family, predominantly explored in organic and main-group organometallic chemistry. Herein, we introduce them to transition-metal coordination by employing N-doped TH...

Introducing Diradicaloid Thiele's Hydrocarbon Derivatives as Ligand in Transition Metal Chemistry

ABSTRACT Thiele's hydrocarbon (TH) derivatives, or p ‐quinodimethanes, are prototypical members of the organic diradicaloid family, predominantly explored in organic and main‐group organometallic chemistry. Herein, we introduce them to transition‐metal coordination by employing N...

Synthesis and evaluation of fluorinated chromene-pyridone as a dual-acting agent against Alzheimer's disease and cancer: biological assessment and computational modelling

The global challenge of neurodegenerative diseases and cancer necessitates new multifunctional therapeutics. We designed and synthesised novel chromene-hydrazone derivatives as multitarget ligands. Structures were confirmed spectroscopically and by X-ray crystallography, with dat...