Binnu Gangadharan

A biochemical mechanism for Stu2/XMAP215-family microtubule polymerases

Abstract Defining quantitative biochemical mechanisms of microtubule dynamics and regulation is a current challenge. Stu2/XMAP215-family polymerases use tubulin-binding TOG domains to catalyze microtubule growth, but how polymerase activity results from the number and tubulinbind...