Binju Wang

Discovery of Stereoselective UrCYP71AU Oxidases Catalyzing the Final Biosynthetic Step of Rhynchophylline and Mechanistic Insights into 7R and 7S Spiroindole Skeleton Formation

Abstract Rhynchophylline (RHY) is a spiroindole alkaloid that acts on the cardiovascular and central nervous systems. Based on the distribution patterns of 7R and 7S spiroindole alkaloids in U. rhynchophylla, we hypothesize the existence of hirsutine oxidase responsible for 7R an...

Janus Reactivity of a Mononuclear Non‐Heme Iron(III)‐Peroxo Complex Toward Indole Oxidation

ABSTRACT Indole oxidation reaction is a pivotal process in organic chemistry, playing a crucial role in the synthesis of various natural products and pharmaceuticals. To‐date, indole oxidation is limited to heme enzymes and synthetic iron porphyrin compounds. Herein, we demonstra...