Bingjing Sun

Differential circadian time modulates of dentate gyrus and CA1 excitation-inhibition balance and seizure threshold

Abstract Circadian rhythms regulate seizure threshold and neuronal excitability in epilepsy. Temporal lobe seizures tend to arise more frequently during the diurnal phase relative to the nocturnal phase, yet dentate gyrus (DG) granule cells display elevated intrinsic excitability...