Bingchen Chen

Performance of a five-gene plasma cfDNA methylation assay for colorectal cancer detection: a single-center real-world analysis

Blood-based circulating cell-free DNA (cfDNA) methylation assays have been proposed as minimally invasive tools for colorectal cancer (CRC) detection, but their performance under routine clinical conditions may differ from model-development studies. We evaluated the real-world di...

Polygonum cuspidatum Exosome‐Like Nanovesicles Alleviate Hypoxic Pulmonary Hypertension by Stabilizing PON1 to Inhibit MAPK ‐Mediated PASMC Phenotypic Switching

Hypoxic pulmonary hypertension (HPH) is characterized by excessive proliferation of pulmonary vascular cells, ultimately resulting in right heart failure and death. Although resveratrol, an active component of Polygonum cuspidatum (PC), has shown efficacy against HPH, the mechani...