Bing Ruan

Tacrolimus attenuates BCL-2/BAX-mediated chondrocyte apoptosis and cartilage matrix degradation in experimental osteoarthritis

Osteoarthritis is a progressive whole-joint disease characterized by cartilage matrix degradation, synovial inflammation and impaired chondrocyte survival. Current pharmacological treatments mainly relieve symptoms and do not reliably prevent structural progression. Here, we inve...