Bilon Khambu

Autophagy regulates the hepatic protein acetylation through modulating acetyl-CoA metabolite

Abstract Post-translational modifications (PTMs) are essential for hepatic protein function and signaling. While autophagy regulates the hepatic proteome through degradation and transcriptional control, its role in PTMs remains unclear. Using genetic and pharmacological models, w...

Alcohol reshapes liver zonal plasticity and immune-metabolic reprogramming in metabolic-syndrome associated hepatocellular carcinoma

Hepatocellular carcinoma (HCC) commonly arises in metabolic dysfunction-associated steatohepatitis (MASH), alcohol-related liver disease (ALD), and metabolic dysfunction-associated ALD (MetALD), yet how zonal metabolic programs govern tumor lineage and immune responses remains un...