Bernhard Nieswandt

When platelets are under pressure: an angiotensin II-TGF-β axis in hypertensive patients leads to receptor PAR4 overexpression

Angiotensin II-TGF-β1-Smad2 signalling promotes PAR4 overexpression and platelet priming in hypertension. The schematic depicts the proposed mechanism by which an angiotensin II-high hypertensive phenotype drives megakaryocyte reprogramming and platelet hyperreactivity. In normos...

Platelet GPVI drives fibrotic lung remodeling

Platelets are a major reservoir of bioactive mediators, including growth factors such as transforming growth factor β1 (TGF-β1), that regulate vascular repair and tissue remodeling. Beyond these classical functions, platelets also participate in inflammatory hemostasis through ac...

Splenic regulation of systemic platelet activation state

Platelets are essential to prevent blood loss and to orchestrate inflammation. Thrombotic complications of vascular disease and hyperresponsive platelets are associated with adverse outcomes, yet physiological mechanisms counteracting systemic platelet activation are poorly defin...