Bernard Jimmy Hanseeuw

Plasma p-tau217 in real-world clinical practice: distribution across clinical diagnostic categories, clinician confidence, and impact on care pathways

Plasma phosphorylated tau at threonine 217 (p-tau217) is a highly accurate blood-based biomarker for Alzheimer’s disease pathology, but evidence regarding its determinants and clinical impact in routine practice remains limited. We evaluated its distribution across real-world cli...

Focal and Steerable Temporal Interference Stimulation of the Human Left Posterior Insula: A Proof-of-Concept Validation Using Intracranial Recordings in a Human Cadaver

The insular cortex, especially its posterior subdivision, is a key hub for interoceptive, somatosensory, and nociceptive processing, making it a compelling target for neuromodulation. However, its depth within the lateral sulcus makes it difficult to reach selectively with conven...

Amygdala shows heterogeneous atrophy and tauopathy patterns across the AD continuum

Abstract Background Amygdala shows early vulnerability in Alzheimer’s disease (AD), although its substructures have been less studied than hippocampal subfields. Neuropathological evidence suggests that tau pathology affects amygdala subnuclei differentially, yet in vivo characte...