Bénédicte F. Py

Bacterial toxin sensing induces transient inflammasome-dependent innate immune memory that improves survival during sepsis

Abstract Adaptive immune memory generated by bacterial toxin vaccination is well established, but whether bacterial toxins can also induce innate immune memory, or trained immunity (TI), remains unclear. Here, we show that bacterial toxins elicit TI through NLRP3 inflammasome act...