Belal Awwad

Intramolecular Stereospecific Skeletal Rearrangement via Nonclassical Carbocations

Abstract A stereospecific, Lewis acid-catalyzed intramolecular nucleophilic substitution at fully substituted carbon stereocenters is described, proceeding through nonclassical cyclopropyl carbinyl (CPC) carbocation intermediates and complete skeletal rearrangement. The method di...