Bauyrzhan Umbayev

Cdc42 in Tumor Hypoxia: Molecular Mechanisms of Cellular Adaptation

Tumor hypoxia is a hallmark of solid tumors that promotes aggressiveness and resistance to therapy. Within hypoxic tumors, hypoxia-inducible factor (HIF)-dependent transcriptional programs drive metabolic reprogramming, lactate accumulation, extracellular acidosis, angiogenesis,...