Basheer Khalil

Expanding the clinical spectrum of DNASE1L3-associated monogenic lupus

Rationale: DNASE1L3 deficiency is a rare autosomal-recessive monogenic form of systemic lupus erythematosus, characterized by defective clearance of extracellular DNA, leading to immune-complex formation, autoantibody production, and systemic inflammation. While early-onset lupus...