Basavaraj R. Patil

Rational Designof Pyrrole-Based Ionizable Lipidsfor mRNA Delivery

Abstract Ionizable lipids are key components of lipid nanoparticles for mRNA delivery. Inspired by the DLin-KC2-DMA ionizable lipid, we developed a series of pyrrole-based ionizable lipids to evaluate the feasibility of incorporating a rigid heterocyclic scaffold into ionizable l...