Baris Bingol

Stimulated protein degradation to promote mitochondrial function and neuronal survival

Targeted protein degradation is a promising modality to treat cancer or inflammation, but whether it can provide a similar benefit for disorders caused by pervasive protein dysregulation is unclear. We describe stimulated protein degradation (SPD) as a strategy that leverages ago...

Intranigral injection of alpha-synuclein pre-formed fibrils leads to BBB compromise and bilateral dopaminergic neurodegeneration in A53T alpha-synuclein transgenic mice

ABSTRACT Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by alpha-(α)-Synuclein neuronal aggregation and loss of dopaminergic (DA) neurons. Developing animal models that replicate PD’s neuropathological phenotypes is critical for understanding i...