Barbara Uzonyi

Human factor H-related protein 5 modulates the classical and lectin complement pathways on selected host ligands

Abstract C4b-binding protein (C4BP) and factor H (FH) are the main soluble negative regulators of the classical/lectin (CP/LP) and alternative (AP) complement pathways, respectively. They do not only act in solution but also interact with host ligands such as C-reactive protein (...