Balyn W. Zaro

Macrophages transfer functional proteins to their surface during live-cell uptake

Abstract A cell’s proteome is assumed to reflect its transcriptional and translational activity. Macrophages regularly acquire xenobiotic material from neighboring cells, which is thought to result in degradation of the material. However, increasing lines of evidence suggest that...

Ibrutinib therapy results in atrial fibrillation through modulation of the Src-Erk1/2 pathway

The Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib has revolutionized treatment for B-cell malignancies but increases the incidence of atrial fibrillation (AF) compared to conventional chemotherapy. The downstream signaling pathways through which ibrutinib leads to AF are unk...