Balasubramanian Narasimhan

Univariate-guided sparse regression for Biobank-scale high-dimensional omics data

We present a scalable framework for computing polygenic risk scores (PRS) in high-dimensional genomic settings using the recently introduced Univariate-Guided Sparse Regression (uniLasso). UniLasso is a two-stage penalized regression procedure that leverages univariate coefficien...

Epithelial-mesenchymal Wnt crosstalk directs planar cell polarity in the developing cochlea

Cochlear hair cells are precisely oriented by planar cell polarity. Wnt proteins direct planar cell polarity in vertebrates, but their roles in regulating cochlear planar cell polarity remain unclear. Here, we inhibit Wnt secretion by ablating epithelial Wntless and find shortene...