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Design, Synthesis, and Biological Evaluation of Novel Dithiocarbamate-Based Human Carbonic Anhydrase IX/XII Inhibitors as Potential Anti-Glioblastoma Agents

To develop human carbonic anhydrase (hCA) IX/XII-targeted therapeutics for glioblastoma multiforme (GBM), novel dithiocarbamate (DTC)-based compounds were synthesized and evaluated for their inhibitory activity against hCA I, II, IX, and XII isoforms. The most potent hCA IX/XII i...