Ayisha Zia

Chemical Editing Reveals Atomic-Level Control of Supramolecular Structure in Self-Assembling Peptides

Abstract Can replacement of single atoms within amino acid sequences redirect peptide self-assembly into different supramolecular structures? To address this question, we investigated a compositionally similar class of bola-amphiphilic peptides that were designed to self-assemble...

In Situ Multiscale Imaging Reveals Cellular Selection and Remodeling of Peptide Assemblies from Membrane Perturbation to Actin Dysregulation

Abstract Enzyme-responsive peptide nanomaterials can induce non-apoptotic cancer cell death, yet the supramolecular states that mediate activity in cellular environments are usually inferred rather than directly resolved. Here, we integrate multiscale in situ imaging with biochem...

A bundled anti-parallel cytochrome nanowire structure suggests roles in cell-cell electron transfer and biofilm formation

ABSTRACT Long-range extracellular electron transfer enables respiring microbes to use minerals, organisms, or electrodes as electron acceptors by transporting electrons microns away from the cell surface. This process is primarily studied in Geobacter sulfurreducens , which produ...