Atsushi Kumanogoh

Epitope-diverse autoantibodies induce neutrophil–epithelial niches driving kidney injury in ANCA-associated glomerulonephritis

Autoantibody-mediated inflammation drives tissue injury in autoimmune diseases, yet how pathogenic antibodies evoke local immune activation remains poorly understood. Here, we show that spatially organized neutrophil-epithelial niches contribute to kidney injury in myeloperoxidas...

Complement profiling and neutrophil single-cell analysis reveal inflammation via the classical complement pathway in Behçet’s syndrome

Behçet’s syndrome (BS) is a systemic immune-mediated disorder characterised by recurrent mucocutaneous, skin, and ocular inflammation, with severe neurological, vascular, or gastrointestinal involvement in some individuals. Although neutrophilic inflammation is considered central...

Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination disseminated in space and time. Here we performed a genome-wide association study (GWAS) using 688 MS cases and 205,199 controls from the Japanese population and...