Atiqullah Sadaqat

Palpitations in children and adolescents in the emergency department: a state-of-the-art narrative review of arrhythmia risk, diagnostic strategy, and disposition

BACKGROUND: Palpitations are not an uncommon complaint in the paediatric emergency department, causing significant anxiety for families concerned about serious heart disease. However, most cases are benign, often stemming from normal physiological responses like fever or anxiety....

High-flow nasal cannula versus conventional oxygen therapy in adults with acute hypoxemic respiratory failure: an updated systematic review, meta-analysis and trial sequential analysis

HFNC oxygen therapy is widely used for acute hypoxemic respiratory failure (AHRF), yet its superiority over conventional oxygen therapy (COT) remains uncertain. This meta-analysis evaluated HFNC efficacy and safety in adults with AHRF. Five databases were searched from January 20...

Efficacy of early blood purification on serum inflammatory mediators in severe acute pancreatitis: a systematic review and meta-analysis

Severe acute pancreatitis (SAP) is the most critical form of acute pancreatitis (AP), characterized by a dysregulated systemic inflammatory response that drives early organ failure and mortality. Current management remains mainly supportive. Early blood purification (EBP) has bee...

Efficacy and safety of oncolytic herpes simplex virus therapy in solid tumors: a systematic review and meta-analysis of 38 clinical trials

Abstract Background Oncolytic herpes simplex virus (oHSV) therapy represents a novel immunotherapeutic approach for solid tumors. Despite regulatory approval of talimogene laherparepvec (T-VEC) for advanced melanoma, comprehensive pooled estimates of efficacy and safety across di...