Ashwin Jainarayanan

Human microglia clear intraneuronal α-synuclein aggregates by GPNMB-mediated trogocytosis

Microglia are the primary immune cells of the brain, but their role in Parkinson’s disease is not fully understood. Chronic microglial activation is toxic to neurons, but in the early stages of pathology, microglia also exert beneficial functions. We used induced pluripotent stem...