Ashrit Talluri

Cryptic splicing as a graded readout of TDP-43 dysfunction: mechanism, biomarkers, and a proposal for threshold-resolved staging across ALS, frontotemporal dementia, and LATE

Nuclear depletion of the RNA-binding protein TDP-43 is the shared molecular lesion of a disease spectrum far broader than the one in which it was discovered. It defines the neuropathology of more than ninety per cent of amyotrophic lateral sclerosis (ALS) and roughly half of fron...