Ashok Aspatwar

Carbonic Anhydrases in Mycobacteria: Linking Metabolic Adaptation to Phenotypic Drug Tolerance

Abstract Tuberculosis (TB) treatment is increasingly challenged by both antimicrobial resistance (AMR) and phenotypic drug tolerance, the latter representing a reversible physiological state that contributes to persistence and prolonged therapy. While AMR is driven by heritable g...

Synthesis and computational evaluation of novel indazole-based benzamide derivatives as anti-tubercular agents via DFT, molecular docking studies

A series of indazole-based benzamide derivatives (6a–6p) were synthesized via amide cross-coupling reactions and characterized using FTIR, NMR, and HRMS techniques. Density functional theory (DFT) and time-dependent DFT (TD-DFT) studies were performed to investigate the electroni...