Arun Richard Chandrasekaran

A Rotary DNA Mazzocchio Nanostructure

Abstract DNA nanotechnology offers architectures ranging from compact motifs to scaffolded origami, with trade-offs in structural complexity, addressability, and component economy. Here, we translate Leonardo da Vinci’s mazzocchio geometry into a programmable DNA assembly. Twenty...

A CRISPR-Cas12a-Responsive DNA Tetrahedron

Abstract Functionalizing DNA nanostructures for stimuli-responsive reconfiguration has been a key area of development in DNA nanotechnology. Here, we demonstrate programmable control over the structural integrity of a tetrahedral DNA nanostructure using an external DNA stimulus t...

DNA Nanotechnology in the Undergraduate Laboratory: Isothermal Assembly and Quantification of DNA Nanostructures

Abstract DNA nanotechnology has proven to have strong potential in several applications. This technology relies on the programmable nature of DNA self-assembly to build structures and motifs with a high level of precision. Most assembly techniques rely on a temperature gradient t...