Arun Mariappan

Uncovering pan-cancer signatures of chemoresistance

Abstract Background Chemotherapy resistance remains a formidable challenge in cancer treatment, driving high mortality rates worldwide. Despite significant advancements, it remains unclear whether conserved molecular programs underpin therapy resistance across cancer types. Metho...

Phosphorylation-dependent control of transcription factor activity regulates temporal patterning of cortical cell fate specification

Abstract The development of the cerebral cortex requires precise temporal control of transcription factor (TF) activity to coordinate neuronal and glial lineage transitions. However, the molecular mechanisms coupling signaling dynamics to TF function remain unclear. Here, we comb...